Target：NAC3

Fields：Calcium signaling pathway;cGMP-PKG signaling pathway;Cardiac muscle contraction;Adrenergic signaling in cardiomyocytes;Apelin signaling pathway;Olfactory transduction;Endocrine and other factor-regulated calcium reabsorption;Protein digestion and absorption;Mineral absorption;Hypertrophic cardiomyopathy;Arrhythmogenic right ventricular cardiomyopathy;Dilated cardiomyopathy

Gene Name：SLC8A3 NCX3

Protein Name：Sodium/calcium exchanger 3 (Na(+)/Ca(2+)-exchange protein 3)

Human Gene Id：6547

Human Swiss Prot No：P57103

Rat Swiss Prot No：P70549

Immunogen：Synthesized peptide derived from human protein . at AA range: 530-610

Specificity：NAC3 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：101kD

Background： This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described. [provided by RefSeq, Aug 2013],

Function：enzyme regulation:By intracellular calcium ions.,function:Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores.,similarity:Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily.,similarity:Contains 2 Calx-beta domains.,tissue specificity:Isoform 2 is expressed in brain and skeletal muscle; Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle; Isoform 4 is expressed in skeletal muscle.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein . Perikaryon . Cell projection, dendrite . Cell projection, dendritic spine . Cell membrane, sarcolemma . Cytoplasm, sarcoplasm . Cell junction . Mitochondrion outer membrane ; Multi-pass membrane protein . Cytoplasm, perinuclear region . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Detected at neuromuscular junctions. .

Expression：Isoform 2 is expressed in brain and skeletal muscle. Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle. Isoform 4 is expressed in skeletal muscle.