Target：Melan-A

Gene Name：MLANA

Protein Name：Melanoma antigen recognized by T-cells 1

Human Gene Id：2315

Human Swiss Prot No：Q16655

Immunogen：The antiserum was produced against synthesized peptide derived from human MART-1. AA range:41-90

Specificity：Melan-A Polyclonal Antibody detects endogenous levels of Melan-A protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MLANA;MART1;Melanoma antigen recognized by T-cells 1;MART-1;Antigen LB39-AA;Antigen SK29-AA;Protein Melan-A

Observed Band(KD)：15kD

Background：tissue specificity:Expression is restricted to melanoma and melanocyte cell lines and retina.,

Function：tissue specificity:Expression is restricted to melanoma and melanocyte cell lines and retina.,

Subcellular Location：Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.

Expression：Expression is restricted to melanoma and melanocyte cell lines and retina.