Target：MEL-1B-R

Fields：Neuroactive ligand-receptor interaction;Circadian entrainment

Gene Name：MTNR1B

Protein Name：Melatonin receptor type 1B

Human Gene Id：4544

Human Swiss Prot No：P49286

Mouse Swiss Prot No：Q8CIQ6

Immunogen：The antiserum was produced against synthesized peptide derived from human MTR1B. AA range:301-350

Specificity：MEL-1B-R Polyclonal Antibody detects endogenous levels of MEL-1B-R protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MTNR1B;Melatonin receptor type 1B;Mel-1B-R;Mel1b receptor

Observed Band(KD)：40kD

Background： This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008],

Function：function:High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.,online information:Melatonin receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in retina and less in brain and hippocampus.,

Subcellular Location：Cell membrane; Multi-pass membrane protein.

Expression：Expressed in retina and less in brain and hippocampus.