Target：MEL-1A-R

Fields：Neuroactive ligand-receptor interaction;Circadian entrainment

Gene Name：MTNR1A

Protein Name：Melatonin receptor type 1A

Human Gene Id：4543

Human Swiss Prot No：P48039

Mouse Gene Id：17773

Mouse Swiss Prot No：Q61184

Rat Swiss Prot No：P49218

Immunogen：The antiserum was produced against synthesized peptide derived from human MTR1A. AA range:191-240

Specificity：MEL-1A-R Polyclonal Antibody detects endogenous levels of MEL-1A-R protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MTNR1A;Melatonin receptor type 1A;Mel-1A-R;Mel1a receptor

Molecular Weight(Da)：39kD

Background： This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008],

Function：function:High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.,online information:Melatonin receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus.,

Subcellular Location：Cell membrane; Multi-pass membrane protein.

Expression：Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus.