Target:MKK7
Fields:MAPK signaling pathway;ErbB signaling pathway;Protein processing in endoplasmic reticulum;Osteoclast differentiation;Tight junction;Toll-like receptor signaling pathway;T cell receptor signaling pathway;Fc epsilon RI signaling pathway;TNF signaling pathway;Neurotrophin signaling pathway;GnRH signaling pathway;Relaxin signaling pathway;Alcoholic liver disease;Alzheimer disease;Huntington disease;Pathways of neurodegeneration - multiple diseases;Salmonella infection;Yersinia infection;Hepatitis B;Kaposi sarcoma-associated herpesvirus infection;Epstein-Barr virus infection;Human immunodeficiency virus 1 infection;Chemical carcinogenesis - reactive oxygen species;Lipid and atherosclerosis;Fluid shear stress and atherosclerosis
Gene Name:MAP2K7
Protein Name:Dual specificity mitogen-activated protein kinase kinase 7
Human Gene Id:5609
Human Swiss Prot No:O14733
Mouse Gene Id:26400
Mouse Swiss Prot No:Q8CE90
Rat Gene Id:363855
Rat Swiss Prot No:Q4KSH7
Immunogen:The antiserum was produced against synthesized peptide derived from human MAP2K7. AA range:241-290
Specificity:MEK-7 Polyclonal Antibody detects endogenous levels of MEK-7 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000;IHC 1:50-300
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:MAP2K7;JNKK2;MEK7;MKK7;PRKMK7;SKK4;Dual specificity mitogen-activated protein kinase kinase 7;MAP kinase kinase 7;MAPKK 7;JNK-activating kinase 2;MAPK/ERK kinase 7;MEK 7;Stress-activated protein kinase kinase 4;SAPK kinase 4;S
Observed Band(KD):47kD
Background: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],
Function:catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation by specific MAP kinase kinase kinases such as MAP3K1/MEKK1, MAP3K3/MEKK3, MAP3K11/MLK3 and MAP3K12/DLK.,function:Stress activated, dual specificity kinase that activates the JUN kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3.,PTM:Activated by phosphorylation on Ser/Thr.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.,
Subcellular Location:Nucleus. Cytoplasm .
Expression:Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.