Target：NVL

Fields：Ribosome biogenesis in eukaryotes

Gene Name：NVL

Protein Name：Nuclear valosin-containing protein-like

Human Gene Id：4931

Human Swiss Prot No：O15381

Mouse Gene Id：67459

Mouse Swiss Prot No：Q9DBY8

Immunogen：Synthesized peptide derived from NVL . at AA range: 320-400

Specificity：NVL Polyclonal Antibody detects endogenous levels of NVL protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：NVL;Nuclear valosin-containing protein-like;NVLp;Nuclear VCP-like protein

Observed Band(KD)：95kD

Background： This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynthesis (PMID: 15469983, 16782053), while the minor isoform has been localized to the nucleoplasmin. [provided by RefSeq, Aug 2011],

Function：PTM:Phosphorylated.,similarity:Belongs to the AAA ATPase family.,tissue specificity:Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina.,

Subcellular Location：[Isoform 2]: Nucleus, nucleoplasm .; [Isoform 1]: Nucleus, nucleolus . Nucleus, nucleoplasm . Expressed predominantly in the nucleolus. Associates with pre-ribosomal particles in the nucleus. .

Expression：Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina.