Target：NU133

Fields：Nucleocytoplasmic transport;Amyotrophic lateral sclerosis

Gene Name：NUP133

Protein Name：Nuclear pore complex protein Nup133 (133 kDa nucleoporin) (Nucleoporin Nup133)

Human Gene Id：55746

Human Swiss Prot No：Q8WUM0

Mouse Swiss Prot No：Q8R0G9

Immunogen：Synthesized peptide derived from human protein . at AA range: 830-910

Specificity：NU133 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：127kD

Background：nucleoporin 133(NUP133) Homo sapiens The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells. [provided by RefSeq, Jul 2008],

Function：function:Involved in poly(A)+ RNA transport.,similarity:Belongs to the nucleoporin Nup133 family.,subcellular location:Located on both the cytoplasmic and nuclear sides of the nuclear pore. During mitosis, localizes to the kinetochores.,subunit:Forms part of the Nup160 subcomplex in the nuclear pore which is composed of Nup160, Nup133, Nup107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and Nup153 to the nucleus.,

Subcellular Location：Nucleus, nuclear pore complex . Chromosome, centromere, kinetochore . Located on both the cytoplasmic and nuclear sides of the nuclear pore (PubMed:11564755). During mitosis, localizes to the kinetochores (PubMed:11564755). .

Expression：Widely expressed in fetal and adult tissues. Expressed in the brain and kidney.