Target：NU107

Fields：Nucleocytoplasmic transport;Amyotrophic lateral sclerosis

Gene Name：NUP107

Protein Name：Nuclear pore complex protein Nup107 (107 kDa nucleoporin) (Nucleoporin Nup107)

Human Gene Id：57122

Human Swiss Prot No：P57740

Mouse Swiss Prot No：Q8BH74

Rat Swiss Prot No：P52590

Immunogen：Synthesized peptide derived from human protein . at AA range: 600-680

Specificity：NU107 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：101kD

Background：nucleoporin 107(NUP107) Homo sapiens This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008],

Function：function:Essential component of nuclear pore complex. Required for the assembly of peripheral proteins into the nuclear pore complex.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the nucleoporin Nup84/Nup107 family.,subcellular location:Located on both the cytoplasmic and nuclear sides of the nuclear pore. During mitosis, localizes to the kinetochores.,subunit:Forms part of the Nup160 subcomplex in the nuclear pore which is composed of Nup160, Nup133, Nup107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and Nup153 to the nucleus.,

Subcellular Location：Nucleus membrane . Nucleus, nuclear pore complex . Chromosome, centromere, kinetochore . Located on both the cytoplasmic and nuclear sides of the NPC core structure (PubMed:11564755). During mitosis, localizes to the kinetochores (PubMed:11564755). Dissociates from the dissasembled NPC structure late during prophase of mitosis (PubMed:11564755). .

Expression：Ubiquitously expressed in fetal and adult tissues.