Target:NT5C1A
Fields:Purine metabolism;Pyrimidine metabolism;Nicotinate and nicotinamide metabolism;Metabolic pathways;Nucleotide metabolism
Gene Name:NT5C1A
Protein Name:Cytosolic 5'-nucleotidase 1A
Human Gene Id:84618
Human Swiss Prot No:Q9BXI3
Mouse Gene Id:230718
Mouse Swiss Prot No:A3KFX0
Immunogen:The antiserum was produced against synthesized peptide derived from human NT5C1A. AA range:151-200
Specificity:NT5C1A Polyclonal Antibody detects endogenous levels of NT5C1A protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:NT5C1A;Cytosolic 5'-nucleotidase 1A;cN1A;Cytosolic 5'-nucleotidase IA;cN-I;cN-IA
Observed Band(KD):41kD
Background: Cytosolic nucleotidases, such as NT5C1A, dephosphorylate nucleoside monophosphates (Hunsucker et al., 2001 [PubMed 11133996]).[supplied by OMIM, Mar 2008],
Function:catalytic activity:A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.,cofactor:Magnesium.,enzyme regulation:Activated by ADP.,function:Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.,similarity:Belongs to the 5'-nucleotidase type 3 family.,tissue specificity:Highly expressed in skeletal muscle. Detected at intermediate levels in heart, brain, kidney and pancreas.,
Subcellular Location:Cytoplasm.
Expression:Highly expressed in skeletal muscle. Detected at intermediate levels in heart, brain, kidney and pancreas.