Target：Nrf3

Gene Name：NFE2L3

Protein Name：Nuclear factor erythroid 2-related factor 3

Human Gene Id：9603

Human Swiss Prot No：Q9Y4A8

Mouse Swiss Prot No：Q9WTM4

Immunogen：The antiserum was produced against synthesized peptide derived from human NFE2L3. AA range:491-540

Specificity：Nrf3 Polyclonal Antibody detects endogenous levels of Nrf3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：NFE2L3;NRF3;Nuclear factor erythroid 2-related factor 3;NF-E2-related factor 3;NFE2-related factor 3;Nuclear factor; erythroid derived 2, like 3

Observed Band(KD)：75kD

Background： This gene encodes a member of the cap 'n' collar basic-region leucine zipper family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18. [provided by RefSeq, Mar 2009],

Function：function:Activates erythroid-specific, globin gene expression.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. CNC subfamily.,similarity:Contains 1 bZIP domain.,subunit:Heterodimer with MAFG, MAFK and other small MAF proteins that binds to the MAF recognition elements (MARE).,tissue specificity:Highly expressed in human placenta and also in B-cell and monocyte cell lines. Low expression in heart, brain, lung, skeletal muscle, kidney and pancreas.,

Subcellular Location：Nucleus .

Expression：Highly expressed in human placenta and also in B-cell and monocyte cell lines. Low expression in heart, brain, lung, skeletal muscle, kidney and pancreas.