Target:PAR-4
Fields:Rap1 signaling pathway;Neuroactive ligand-receptor interaction;Complement and coagulation cascades;Platelet activation;Pathways in cancer
Gene Name:F2RL3
Protein Name:Proteinase-activated receptor 4
Human Gene Id:9002
Human Swiss Prot No:Q96RI0
Mouse Gene Id:14065
Mouse Swiss Prot No:O88634
Rat Gene Id:116498
Rat Swiss Prot No:Q920E0
Immunogen:The antiserum was produced against synthesized peptide derived from human PAR4. AA range:29-78
Specificity:PAR-4 Polyclonal Antibody detects endogenous levels of PAR-4 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:F2RL3;PAR4;Proteinase-activated receptor 4;PAR-4;Coagulation factor II receptor-like 3;Thrombin receptor-like 3
Observed Band(KD):41kD
Background: This gene encodes a member of the protease-activated receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Hypomethylation at this gene may be associated with lung cancer in human patients. [provided by RefSeq, Sep 2016],
Function:function:Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.,PTM:A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Widely expressed, with highest levels in lung, pancreas, thyroid, testis and small intestine. Not expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also detected in platelets.,
Subcellular Location:Cell membrane; Multi-pass membrane protein.
Expression:Widely expressed, with highest levels in lung, pancreas, thyroid, testis and small intestine. Not expressed in brain, kidney, spinal cord and peripheral blood leukocytes. Also detected in platelets.