Target:PAR14
Gene Name:PARP14 BAL2 KIAA1268
Protein Name:Poly [ADP-ribose] polymerase 14 (PARP-14) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 8) (ARTD8) (B aggressive lymphoma protein 2)
Human Gene Id:54625
Human Swiss Prot No:Q460N5
Mouse Swiss Prot No:Q2EMV9
Immunogen:Synthesized peptide derived from part region of human protein
Specificity:PAR14 Polyclonal Antibody detects endogenous levels of protein.
Formulation:Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000 ELISA 1:5000-20000
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD):198kD
Background: This gene encodes a member of the poly(ADP-ribose) polymerase (PARP) protein family. The encoded anti-apoptotic protein may regulate aerobic glycolysis and promote survival of cancer cells. Increased expression of this gene has been reported in a variety of tumor types. [provided by RefSeq, Jul 2016],
Function:catalytic activity:NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.,function:Enhances STAT6-dependent transcription (By similarity). Has ADP-ribosyltransferase activity.,similarity:Contains 1 PARP catalytic domain.,similarity:Contains 1 WWE domain.,similarity:Contains 3 Macro domains.,subcellular location:In steady state cells the protein is mostly nuclear. A minor proportion is detected in the cytoplasm.,subunit:Interacts with STAT6.,
Subcellular Location:Nucleus . Cytoplasm . In steady state splenocytes the protein is mostly nuclear (By similarity). A minor proportion is detected in the cytoplasm (By similarity). In macrophages, mainly localizes to the cytoplasm (PubMed:27796300). .
Expression:Expressed in macrophages.