Target:P55G
Fields:EGFR tyrosine kinase inhibitor resistance;Endocrine resistance;Platinum drug resistance;ErbB signaling pathway;Ras signaling pathway;Rap1 signaling pathway;cAMP signaling pathway;Chemokine signaling pathway;HIF-1 signaling pathway;FoxO signaling pathway;Phosphatidylinositol signaling system;Sphingolipid signaling pathway;Phospholipase D signaling pathway;Autophagy - animal;mTOR signaling pathway;PI3K-Akt signaling pathway;AMPK signaling pathway;Apoptosis;Longevity regulating pathway;Longevity regulating pathway - multiple species;Cellular senescence;Axon guidance;VEGF signaling pathway;Osteoclast differentiation;Focal adhesion;Signaling pathways regulating pluripotency of stem cells;Platelet activation;Neutrophil extracellular trap formation;Toll-like receptor signaling pathway;C-type lectin receptor signaling pathway;JAK-STAT signaling pathway;Natural killer cell mediated cytotoxicity;T cell receptor signaling pathway;>
Gene Name:PIK3R3
Protein Name:Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 5
Human Gene Id:8503
Human Swiss Prot No:Q92569
Mouse Swiss Prot No:Q64143
Rat Swiss Prot No:Q63789
Immunogen:Synthesized peptide derived from part region of human protein
Specificity:P55G Polyclonal Antibody detects endogenous levels of protein.
Formulation:Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000 ELISA 1:5000-20000
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD):50kD
Background: Phosphatidylinositol 3-kinase (PI3K) phosphorylates phosphatidylinositol and similar compounds, which then serve as second messengers in growth signaling pathways. PI3K is composed of a catalytic and a regulatory subunit. The protein encoded by this gene represents a regulatory subunit of PI3K. The encoded protein contains two SH2 domains through which it binds activated protein tyrosine kinases to regulate their activity. [provided by RefSeq, Jun 2016],
Function:function:Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.,similarity:Belongs to the PI3K p85 subunit family.,similarity:Contains 2 SH2 domains.,subunit:Heterodimer of a p110 (catalytic) and a p55 (regulatory) subunits.,tissue specificity:Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle.,
Subcellular Location:cytosol,phosphatidylinositol 3-kinase complex,
Expression:Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle.