Target：PD2R

Fields：Neuroactive ligand-receptor interaction

Gene Name：PTGDR

Protein Name：Prostaglandin D2 receptor

Human Gene Id：5729

Human Swiss Prot No：Q13258

Mouse Swiss Prot No：P70263

Immunogen：The antiserum was produced against synthesized peptide derived from human PTGDR. AA range:263-312

Specificity：PD2R Polyclonal Antibody detects endogenous levels of PD2R protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PTGDR;Prostaglandin D2 receptor;PGD receptor;PGD2 receptor;Prostanoid DP receptor

Observed Band(KD)：40kD

Background： This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein is reported to be a receptor for prostaglandin D2, which is a mediator of allergic inflammation and allergic airway inflammation in asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],

Function：disease:Genetic variations in PTGDR are associated with susceptibility to asthma-related traits type 1 (ASRT1) [MIM:607277]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea.,function:Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in retinal choroid, ciliary epithelium, longitudinal and circular ciliary muscles, iris, small intestine and platelet membranes.,

Subcellular Location：Cell membrane ; Multi-pass membrane protein .

Expression：Expressed in retinal choroid, ciliary epithelium, longitudinal and circular ciliary muscles, iris, small intestine and platelet membranes.