Target：PCY1A

Fields：Phosphonate and phosphinate metabolism;Glycerophospholipid metabolism;Metabolic pathways;Choline metabolism in cancer

Gene Name：PCYT1A CTPCT PCYT1

Protein Name：Choline-phosphate cytidylyltransferase A (EC 2.7.7.15) (CCT-alpha) (CTP:phosphocholine cytidylyltransferase A) (CCT A) (CT A) (Phosphorylcholine transferase A)

Human Gene Id：5130

Human Swiss Prot No：P49585

Mouse Swiss Prot No：P49586

Rat Swiss Prot No：P19836

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：PCY1A Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：40kD

Background： This gene belongs to the cytidylyltransferase family and is involved in the regulation of phosphatidylcholine biosynthesis. Mutations in this gene are associated with spondylometaphyseal dysplasia with cone-rod dystrophy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2015],

Function：catalytic activity:CTP + choline phosphate = diphosphate + CDP-choline.,enzyme regulation:By phosphorylation.,function:Controls phosphatidylcholine synthesis.,pathway:Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.,PTM:The serine residues of the C-terminus are phosphorylated. The inactive soluble form is stabilized by phosphorylation, the active membrane bound form is promoted by anionic lipids or diacylglycerol, and is stabilized by dephosphorylation.,similarity:Belongs to the cytidylyltransferase family.,subcellular location:It can interconvert between an inactive cytosolic form and an active membrane-bound form.,subunit:Homodimer; disulfide-linked.,

Subcellular Location：Cytoplasm, cytosol . Membrane ; Peripheral membrane protein . Endoplasmic reticulum . Nucleus . It can interconvert between an inactive cytosolic form and an active membrane-bound form. .

Expression：Brain, placenta, liver, fetal and adult lung.