Target：PI 3-Kinase p110γ

Fields：Inositol phosphate metabolism;Metabolic pathways;cGMP-PKG signaling pathway;Chemokine signaling pathway;Phospholipase D signaling pathway;PI3K-Akt signaling pathway;Adrenergic signaling in cardiomyocytes;Apelin signaling pathway;Platelet activation;Cholinergic synapse;Oxytocin signaling pathway;Salmonella infection;Toxoplasmosis;Kaposi sarcoma-associated herpesvirus infection

Gene Name：PIK3CG

Protein Name：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Human Gene Id：5294

Human Swiss Prot No：P48736

Mouse Swiss Prot No：Q9JHG7

Immunogen：The antiserum was produced against synthesized peptide derived from human PIK3CG. AA range:881-930

Specificity：PI 3-Kinase p110γ Polyclonal Antibody detects endogenous levels of PI 3-Kinase p110γ protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PIK3CG;Phosphatidylinositol 4;5-bisphosphate 3-kinase catalytic subunit gamma isoform;PI3-kinase subunit gamma;PI3K-gamma;PI3Kgamma;PtdIns-3-kinase subunit gamma;Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit

Observed Band(KD)：120kD

Background： Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta), the encoded protein binds a p85 regulatory subunit to form PI3K. This gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2015],

Function：catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.,enzyme regulation:Activated by both the alpha and the beta-gamma G proteins.,function:3-phosphorylates the cellular phosphoinositide PtdIns-4,5-biphosphate (PtdIns(4,5)P2) to produce PtdIns-3, 4,5-triiphosphate (PtdIns(3,4,5)P3). Links G-protein coupled receptor activation to the secondary messenger PtdIns(3,4,5)P3 production.,pathway:Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.,similarity:Belongs to the PI3/PI4-kinase family.,similarity:Contains 1 PI3K/PI4K domain.,subunit:Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit.,tissue specificity:Pancreas, skeletal muscle, liver and heart.,

Subcellular Location：Cytoplasm . Cell membrane .

Expression：Pancreas, skeletal muscle, liver and heart.