Target：PRPF31
Fields：Spliceosome
Gene Name：PRPF31
Protein Name：U4/U6 small nuclear ribonucleoprotein Prp31
Human Gene Id：26121
Human Swiss Prot No：Q8WWY3
Mouse Gene Id：68988
Mouse Swiss Prot No：Q8CCF0
Immunogen：The antiserum was produced against synthesized peptide derived from human PRP31. AA range:331-380
Specificity：PRPF31 Polyclonal Antibody detects endogenous levels of PRPF31 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：PRPF31;PRP31;U4/U6 small nuclear ribonucleoprotein Prp31;Pre-mRNA-processing factor 31;Serologically defined breast cancer antigen NY-BR-99;U4/U6 snRNP 61 kDa protein;Protein 61K;hPrp31
Observed Band(KD)：55kD
Background： This gene encodes a component of the spliceosome complex and is one of several retinitis pigmentosa-causing genes. When the gene product is added to the spliceosome complex, activation occurs.[provided by RefSeq, Jan 2009],
Function：disease:Defects in PRPF31 are the cause of retinitis pigmentosa type 11 (RP11) [MIM:600138]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP11 inheritance is autosomal dominant.,function:Involved in pre-mRNA splicing. Required for U4/U6.U5 tri-snRNP formation.,similarity:Contains 1 Nop domain.,subcellular location:Predominantly found in speckles and in Cajal bodies.,subunit:Part of a tri-snRNP complex. Interacts with C20orf14/U5 snRNP-associated 102 kDa protein.,tissue specificity:Ubiquitously expressed.,
Subcellular Location：Nucleus . Nucleus speckle . Nucleus, Cajal body . Predominantly found in speckles and in Cajal bodies. .
Expression：Ubiquitously expressed.
