Target：PRPF18

Fields：Spliceosome

Gene Name：PRPF18

Protein Name：Pre-mRNA-splicing factor 18

Human Gene Id：8559

Human Swiss Prot No：Q99633

Mouse Gene Id：67229

Mouse Swiss Prot No：Q8BM39

Rat Gene Id：171552

Rat Swiss Prot No：Q9JKB8

Immunogen：The antiserum was produced against synthesized peptide derived from human PRPF18. AA range:182-231

Specificity：PRPF18 Polyclonal Antibody detects endogenous levels of PRPF18 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PRPF18;HPRP18;Pre-mRNA-splicing factor 18;PRP18 homolog;hPRP18

Observed Band(KD)：40kD

Background： Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to the yeast splicing factor Prp18. [provided by RefSeq, Jul 2008],

Function：function:Participates in the second step of pre-mRNA splicing.,similarity:Belongs to the PRP18 family.,subcellular location:Colocalizes with spliceosomal snRNPs.,subunit:Heterodimer with PPIH. Interacts with PRPF4 and with the spliceosome. Part of a complex containing U4/U6 snRNPs.,

Subcellular Location：Nucleus speckle . Colocalizes with spliceosomal snRNPs. .

Expression： Brain,Cervix carcinoma,Placenta,