Target：PROX1

Gene Name：PROX1

Protein Name：Prospero homeobox protein 1 (Homeobox prospero-like protein PROX1) (PROX-1)

Human Gene Id：5629

Human Swiss Prot No：Q92786

Mouse Swiss Prot No：P48437

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：PROX1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：81kD

Background： The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012],

Function：function:May play a fundamental role in early development of CNS. May regulate gene expression and development of postmitotic undifferentiated young neurons.,similarity:Belongs to the Prospero homeobox family.,similarity:Contains 1 Prospero-type homeobox DNA-binding domain.,tissue specificity:Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.,

Subcellular Location：Nucleus . RORG promotes its nuclear localization. .

Expression：Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.