Target：Protocadherin-11

Gene Name：PCDH11X/PCDH11Y

Protein Name：Protocadherin-11 X/Y-linked

Human Gene Id：83259/27328

Human Swiss Prot No：Q9BZA8/Q9BZA7

Immunogen：The antiserum was produced against synthesized peptide derived from human PCDH-X/Y. AA range:531-580

Specificity：Protocadherin-11 Polyclonal Antibody detects endogenous levels of Protocadherin-11 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PCDH11Y;PCDH11;PCDH22;PCDHY;Protocadherin-11 Y-linked;Protocadherin-11;Protocadherin on the Y chromosome;PCDH-Y;Protocadherin prostate cancer;Protocadherin-PC;Protocadherin-22;PCDH11X;KIAA1326;PCDH11;PCDHX;Protocadherin-11 X-

Molecular Weight(Da)：147kD

Background： This gene belongs to the protocadherin family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing seven cadherin repeats, a transmembrane domain, and a cytoplasmic tail that differs from those of the classical cadherins. This gene is located on the Y chromosome in a block of X/Y homology and is very closely related to its paralog on the X chromosome. The protein is thought to play a role in cell-cell recognition during development of the central nervous system. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013],

Function：alternative products:Additional isoforms seem to exist,disease:A chromosomal aberration involving PCDH11Y is a cause of multiple congenital abnormalities, including severe bilateral vesicoureteral reflux (VUR) with ureterovesical junction defects. Translocation t(Y;3)(p11;p12) with ROBO2.,function:Potential calcium-dependent cell-adhesion protein.,similarity:Contains 7 cadherin domains.,subunit:Interacts with CTNNB1.,tissue specificity:Expressed strongly in fetal brain and brain (cortex, amygdala, thalamus, substantia nigra, hippocampus, caudate nucleus and corpus callosum). Expressed at low level in testis. Expressed in apoptosis-resistant cells.,

Subcellular Location：Cell membrane ; Single-pass type I membrane protein .

Expression：Expressed strongly in fetal brain and brain (cortex, amygdala, thalamus, substantia nigra, hippocampus, caudate nucleus and corpus callosum). Expressed at low level in testis. Expressed in apoptosis-resistant cells.