Target：PROF1

Fields：Rap1 signaling pathway;Regulation of actin cytoskeleton;Amyotrophic lateral sclerosis;Shigellosis;Salmonella infection

Gene Name：PFN1

Protein Name：Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I)

Human Gene Id：5216

Human Swiss Prot No：P07737

Mouse Swiss Prot No：P62962

Rat Swiss Prot No：P62963

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：PROF1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：15kD

Background： This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1. [provided by RefSeq, Jul 2012],

Function：function:Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.,similarity:Belongs to the profilin family.,subunit:Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio. Found in a complex with XPO6, Ran, ACTB and PFN1.,

Subcellular Location：Cytoplasm, cytoskeleton.

Expression：Expressed in epididymis (at protein level).