Target：Probetacellulin
Fields：ErbB signaling pathway
Gene Name：BTC
Protein Name：Probetacellulin
Human Gene Id：685
Human Swiss Prot No：P35070
Mouse Gene Id：12223
Mouse Swiss Prot No：Q05928
Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human BTC. AA range:21-70
Specificity：Probetacellulin Polyclonal Antibody detects endogenous levels of Probetacellulin protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：BTC;Probetacellulin
Observed Band(KD)：20kD
Background： This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients. [provided by RefSeq, Nov 2015],
Function：disease:Betacellulin from beta cells could play a role in the vascular complications associated with diabetes.,function:Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. The effects of betacellulin are probably mediated by the EGF receptor and other related receptors.,similarity:Contains 1 EGF-like domain.,subunit:Monomer.,tissue specificity:Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine.,
Subcellular Location：[Betacellulin]: Secreted, extracellular space.; [Probetacellulin]: Cell membrane; Single-pass type I membrane protein.
Expression：Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine.
