Target：PRDM3

Gene Name：MECOM

Protein Name：MDS1 and EVI1 complex locus protein MDS1

Human Gene Id：4197

Human Swiss Prot No：Q13465

Mouse Swiss Prot No：Q9Z1L8

Immunogen：The antiserum was produced against synthesized peptide derived from human MECOM. AA range:1-50

Specificity：PRDM3 Polyclonal Antibody detects endogenous levels of PRDM3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：MECOM;MDS1;MDS1 and EVI1 complex locus protein MDS1;Myelodysplasia syndrome 1 protein;Myelodysplasia syndrome-associated protein 1

Observed Band(KD)：18kD

Background： The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011],

Function：disease:A chromosomal aberration involving EVI1 is a cause of chronic myelogenous leukemia (CML). Translocation t(3;21)(q26;q22) with RUNX1/AML1.,disease:A chromosomal aberration involving MDS1 is found in a form of acute myeloid leukemia (AML). Translocation t(3;21) with AML1.,miscellaneous:Can be produced either as a separate transcript and as a normal fusion transcript with EVI1.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 10 C2H2-type zinc fingers.,subunit:May interact with CTBP1.,

Subcellular Location：histone deacetylase complex,nucleus,nucleoplasm,cytoplasm,Golgi apparatus,cytosol,aggresome,nuclear speck,intracellular membrane-bounded organelle,

Expression： Kidney,Pancreas,