Target:PPP1R14D
Gene Name:PPP1R14D
Protein Name:Protein phosphatase 1 regulatory subunit 14D
Human Gene Id:54866
Human Swiss Prot No:Q9NXH3
Mouse Swiss Prot No:Q7TT52
Immunogen:The antiserum was produced against synthesized peptide derived from human PPP1R14D. AA range:66-115
Specificity:PPP1R14D Polyclonal Antibody detects endogenous levels of PPP1R14D protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:PPP1R14D;GBPI;Protein phosphatase 1 regulatory subunit 14D;Gastrointestinal and brain-specific PP1-inhibitory protein 1;GBPI-1
Observed Band(KD):24kD
Background: Protein phosphatase-1 (PP1; see MIM 176875) is a major cellular phosphatase that reverses serine/threonine protein phosphorylation. PPP1R14D is a PP1 inhibitor that itself is regulated by phosphorylation (Liu et al., 2004 [PubMed 12974676]).[supplied by OMIM, Feb 2010],
Function:function:Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.,PTM:Phosphorylated on several residues.,similarity:Belongs to the PP1 inhibitor family.,tissue specificity:Detected in colon, intestine, kidney and brain cortex.,
Subcellular Location:Cytoplasm .
Expression:Detected in colon, intestine, kidney and brain cortex.