Target:PTH2R
Fields:Neuroactive ligand-receptor interaction
Gene Name:PTH2R PTHR2
Protein Name:Parathyroid hormone 2 receptor (PTH2 receptor)
Human Gene Id:5746
Human Swiss Prot No:P49190
Mouse Swiss Prot No:Q91V95
Rat Swiss Prot No:P70555
Immunogen:Synthesized peptide derived from human protein . at AA range: 160-240
Specificity:PTH2R Polyclonal Antibody detects endogenous levels of protein.
Formulation:Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000 ELISA 1:5000-20000
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD):60kD
Background: The protein encoded by this gene is a member of the G-protein coupled receptor 2 family. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013],
Function:function:This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor.,similarity:Belongs to the G-protein coupled receptor 2 family.,subunit:Binds to TIPF39/TIP39.,tissue specificity:Expressed abundantly in brain and pancreas. Also expressed in the testis.,
Subcellular Location:Cell membrane; Multi-pass membrane protein.
Expression:Expressed abundantly in brain and pancreas. Also expressed in the testis.