Target：TAF II p68

Fields：Basal transcription factors;Transcriptional misregulation in cancer

Gene Name：TAF15

Protein Name：TATA-binding protein-associated factor 2N

Human Gene Id：8148

Human Swiss Prot No：Q92804

Immunogen：The antiserum was produced against synthesized peptide derived from human TAF15. AA range:351-400

Specificity：TAF II p68 Polyclonal Antibody detects endogenous levels of TAF II p68 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TAF15;RBP56;TAF2N;TATA-binding protein-associated factor 2N;68 kDa TATA-binding protein-associated factor;TAF(II)68;TAFII68;RNA-binding protein 56

Observed Band(KD)：62kD

Background： This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012],

Function：disease:A chromosomal aberration involving TAF15/TAF2N is found in a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with NR4A3.,function:RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II).,PTM:Arg-206 is dimethylated, probably to asymmetric dimethylarginine.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the RRM TET family.,similarity:Contains 1 RanBP2-type zinc finger.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Belongs to the RNA polymerase II (Pol II) transcriptional multiprotein complex, together with the TATA-binding protein (TBP) and other TBP-associated factors (TAF(II)s). Binds SF1.,tissue specificity:Ubiquitous. Observed in all fetal and adult ti

Subcellular Location：Nucleus . Cytoplasm . Shuttles from the nucleus to the cytoplasm.

Expression：Ubiquitous. Observed in all fetal and adult tissues.