Target：TAF II p250

Fields：Basal transcription factors

Gene Name：TAF1

Protein Name：Transcription initiation factor TFIID subunit 1

Human Gene Id：6872

Human Swiss Prot No：P21675

Mouse Swiss Prot No：Q80UV9

Immunogen：The antiserum was produced against synthesized peptide derived from human TAF1. AA range:1131-1180

Specificity：TAF II p250 Polyclonal Antibody detects endogenous levels of TAF II p250 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TAF1;BA2R;CCG1;CCGS;TAF2A;Transcription initiation factor TFIID subunit 1;Cell cycle gene 1 protein;TBP-associated factor 250 kDa;p250;Transcription initiation factor TFIID 250 kDa subunit;TAF(II)250;TAFII-250;TAFII250

Molecular Weight(Da)：213kD

Background： Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also bin

Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,disease:Defects in TAF1 are the cause of dystonia type 3 (DYT3) [MIM:314250]; also called X-linked dystonia-parkinsonism (XDP). DYT3 is a X-linked dystonia-parkinsonism disorder. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT3 is characterized by severe progressive torsion dystonia followed by parkinsonism. Its prevalence is high in the Philippines. DYT3 has a well-defined pathology of extensive neuronal loss and mosaic gliosis in the striatum (caudate nucleus and putamen) which appears to resemble that in Huntington disease.,enzyme regulation:Autophosphorylates on Ser residues. Inhibited by retinoblastoma tumor suppressor protein, RB1.,function:Largest component and core scaffold of the TFIID basal transcription factor complex. Conta

Subcellular Location：Nucleus .

Expression： Brain,Fetal brain,Laryngeal carcinoma,