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Tensin-2 Polyclonal Antibody
Tensin-2 Polyclonal Antibody
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Tensin-2 Polyclonal Antibody
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经销商客户: ¥440.0
实验室客户: ¥600.0
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商品描述

商品属性

Target:Tensin-2

Gene Name:TENC1

Protein Name:Tensin-like C1 domain-containing phosphatase

Human Gene Id:23371

Human Swiss Prot No:Q63HR2

Mouse Gene Id:209039

Mouse Swiss Prot No:Q8CGB6

Immunogen:The antiserum was produced against synthesized peptide derived from human Tensin-2. AA range:439-488

Specificity:Tensin-2 Polyclonal Antibody detects endogenous levels of Tensin-2 protein.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source:Polyclonal, Rabbit,IgG

Dilution:WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration:1 mg/ml

Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name:TENC1;KIAA1075;TNS2;Tensin-like C1 domain-containing phosphatase;C1 domain-containing phosphatase and tensin homolog;C1-TEN;Tensin-2

Observed Band(KD):125kD

Background: The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008],

Function:function:Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling.,similarity:Contains 1 C2 tensin-type domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 phosphatase tensin-type domain.,similarity:Contains 1 SH2 domain.,subcellular location:Detected at the end of actin stress fibers.,subunit:Interacts with AXL.,tissue specificity:Detected in heart, kidney, brain, thymus, spleen, liver, placenta, lung, skeletal muscle and small intestine.,

Subcellular Location:Cell junction, focal adhesion . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Detected at the end of actin stress fibers. Detected in cytoplasmic punctate bodies (PubMed:22019427). .

Expression:Detected in heart, kidney, brain, thymus, spleen, liver, placenta, lung, skeletal muscle and small intestine.

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