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Tensin-1 Polyclonal Antibody
Tensin-1 Polyclonal Antibody
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Tensin-1 Polyclonal Antibody
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经销商客户: ¥440.0
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商品属性

Target:Tensin-1

Gene Name:TNS1

Protein Name:Tensin-1

Human Gene Id:7145

Human Swiss Prot No:Q9HBL0

Immunogen:The antiserum was produced against synthesized peptide derived from human Tensin-1. AA range:1273-1322

Specificity:Tensin-1 Polyclonal Antibody detects endogenous levels of Tensin-1 protein.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source:Polyclonal, Rabbit,IgG

Dilution:WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration:1 mg/ml

Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name:TNS1;TNS;Tensin-1

Observed Band(KD):200kD

Background: The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015],

Function:function:May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton.,PTM:Rapidly cleaved by calpain II.,PTM:Tyrosine phosphorylated.,similarity:Contains 1 C2 tensin-type domain.,similarity:Contains 1 phosphatase tensin-type domain.,similarity:Contains 1 SH2 domain.,subunit:Binds to actin filaments and interacts with phosphotyrosine-containing proteins. Interacts with STARD8.,tissue specificity:Ubiquitous.,

Subcellular Location:Cell surface . Cell junction, focal adhesion . Cytoplasm, cytoskeleton . Localized at cell periphery preferentially to fibrillar adhesions than focal adhesions. Translocates from the cell edge to cell center in an ITGB1BP1-dependent manner.

Expression:Ubiquitous.

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