Target：TENN

Fields：PI3K-Akt signaling pathway;Focal adhesion;ECM-receptor interaction;Human papillomavirus infection;MicroRNAs in cancer

Gene Name：TNN

Protein Name：Tenascin-N (TN-N)

Human Gene Id：63923

Human Swiss Prot No：Q9UQP3

Mouse Swiss Prot No：Q80Z71

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：TENN Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：142kD

Background：function:Involved in neurite outgrowth and cell migration in hippocampal explants.,similarity:Belongs to the tenascin family.,similarity:Contains 1 fibrinogen C-terminal domain.,similarity:Contains 3 EGF-like domains.,similarity:Contains 9 fibronectin type-III domains.,

Function：function:Involved in neurite outgrowth and cell migration in hippocampal explants.,similarity:Belongs to the tenascin family.,similarity:Contains 1 fibrinogen C-terminal domain.,similarity:Contains 3 EGF-like domains.,similarity:Contains 9 fibronectin type-III domains.,

Subcellular Location：Secreted, extracellular space, extracellular matrix .

Expression：Not detected in normal adult mammary tissues or brain but expressed in most breast tumors and brain tumors, such as glioblastomas, astrocytomas and oligodendrogliomas, tested (PubMed:17909022, PubMed:19884327). In brain tumors, detected around the endothelial cell layer of the clood vessels (PubMed:19884327).