Target：Tenascin-R
Fields：PI3K-Akt signaling pathway;Focal adhesion;ECM-receptor interaction;Human papillomavirus infection;MicroRNAs in cancer
Gene Name：TNR
Protein Name：Tenascin-R (TN-R) (Janusin) (Restrictin)
Human Gene Id：7143
Human Swiss Prot No：Q92752
Mouse Gene Id：21960
Mouse Swiss Prot No：Q8BYI9
Rat Swiss Prot No：Q05546
Immunogen：Synthetic peptide from human protein at AA range: 1270-1350
Specificity：The antibody detects endogenous Tenascin-R
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：Tenascin-R (TN-R;Janusin;Restrictin)
Background：tenascin R(TNR) Homo sapiens This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The encoded protein is restricted to the central nervous system. The protein may play a role in neurite outgrowth, neural cell adhesion and modulation of sodium channel function. It is a constituent of perineuronal nets. [provided by RefSeq, Aug 2013],
Function：domain:The EGF-like domains mediate interaction with CNTN1. The fibronectin type-III domains 3-5 mediate interaction with BCAN. The fibronectin type-III domains 1-2 and 7-9 mediate interaction with SCN2B.,function:Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clusteri
Subcellular Location：Secreted, extracellular space, extracellular matrix.
Expression：Brain specific.
