Target:Tenascin-C
Fields:PI3K-Akt signaling pathway;Focal adhesion;ECM-receptor interaction;Human papillomavirus infection;MicroRNAs in cancer
Gene Name:TNC
Protein Name:Tenascin
Human Gene Id:3371
Human Swiss Prot No:P24821
Mouse Gene Id:21923
Mouse Swiss Prot No:Q80YX1
Immunogen:The antiserum was produced against synthesized peptide derived from the C-terminal region of human TNC. AA range:2151-2200
Specificity:Tenascin-C Polyclonal Antibody detects endogenous levels of Tenascin-C protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:10000.. IF 1:50-200
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:TNC;HXB;Tenascin;TN;Cytotactin;GMEM;GP 150-225;Glioma-associated-extracellular matrix antigen;Hexabrachion;JI;Myotendinous antigen;Neuronectin;Tenascin-C;TN-C
Observed Band(KD):240kD
Background:tenascin C(TNC) Homo sapiens This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011],
Function:alternative products:Isoforms are produced in a tissue- and time-specific manner during development,function:Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.,induction:By TGF-beta.,PTM:N-glycosylated.,similarity:Belongs to the tenascin family.,similarity:Contains 1 fibrinogen C-terminal domain.,similarity:Contains 15 EGF-like domains.,similarity:Contains 15 fibronectin type-III domains.,subunit:Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the ce
Subcellular Location:Secreted, extracellular space, extracellular matrix.
Expression: Brain,Fetal brain,Fetal cartilage,Glioblastoma,Human fetal kidney,Liver,Melanoma,Milk,Plasma,