Target:TEM7
Gene Name:PLXDC1
Protein Name:Plexin domain-containing protein 1
Human Gene Id:57125
Human Swiss Prot No:Q8IUK5
Mouse Swiss Prot No:Q91ZV7
Immunogen:The antiserum was produced against synthesized peptide derived from human PLXDC1. AA range:71-120
Specificity:TEM7 Polyclonal Antibody detects endogenous levels of TEM7 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:PLXDC1;TEM3;TEM7;Plexin domain-containing protein 1;Tumor endothelial marker 3;Tumor endothelial marker 7
Molecular Weight(Da):56kD
Background:PTM:N-glycosylated.,similarity:Belongs to the plexin family.,subunit:May interact with cortactin.,tissue specificity:Detected in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. Not detectable in endothelial cells from normal tissue.,
Function:PTM:N-glycosylated.,similarity:Belongs to the plexin family.,subunit:May interact with cortactin.,tissue specificity:Detected in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. Not detectable in endothelial cells from normal tissue.,
Subcellular Location:[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells.; [Isoform 2]: Secreted .; [Isoform 3]: Secreted .; [Isoform 4]: Cytoplasm .
Expression:Detected in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. Not detectable in endothelial cells from normal tissue. Expressed in fibrovascular membrane with increased expression in individuals with proliferative diabetic retinopathy.