Target:TBX2/3
Fields:Signaling pathways regulating pluripotency of stem cells
Gene Name:TBX2/TBX3
Protein Name:T-box transcription factor TBX2/3
Human Gene Id:6926
Human Swiss Prot No:O15119/Q13207
Mouse Gene Id:21386/21385
Rat Gene Id:353305
Rat Swiss Prot No:Q7TST9
Immunogen:The antiserum was produced against synthesized peptide derived from human TBX3. AA range:271-320
Specificity:TBX2/3 Polyclonal Antibody detects endogenous levels of TBX2/3 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:TBX3;T-box transcription factor TBX3;T-box protein 3;TBX2;T-box transcription factor TBX2;T-box protein 2
Observed Band(KD):79kD
Background: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. [provided by RefSeq, Jul 2008],
Function:disease:Defects in TBX3 are the cause of ulnar-mammary syndrome (UMS) [MIM:181450]. UMS is characterized by ulnar ray defects, obesity, hypogenitalism, delayed puberty, hypoplasia of nipples and apocrine glands.,function:Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation.,similarity:Contains 1 T-box DNA-binding domain.,tissue specificity:Widely expressed.,
Subcellular Location:Nucleus .
Expression:Widely expressed.