Target：TLN2

Fields：Rap1 signaling pathway;Focal adhesion;Platelet activation;Shigellosis;Human T-cell leukemia virus 1 infection

Gene Name：TLN2 KIAA0320

Protein Name：Talin-2

Human Gene Id：83660

Human Swiss Prot No：Q9Y4G6

Mouse Swiss Prot No：Q71LX4

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：TLN2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:50-300. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：279kD

Background： This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton. [provided by RefSeq, Jul 2008],

Function：function:As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity.,similarity:Contains 1 FERM domain.,similarity:Contains 1 I/LWEQ domain.,subcellular location:Focal adhesion plaques and synapses.,subunit:Interacts directly with PIP5K1C.,

Subcellular Location：Cytoplasm . Cell junction, focal adhesion . Cell junction, synapse . Cell membrane; Peripheral membrane protein; Cytoplasmic side . Cytoplasm, cytoskeleton . Focal adhesion plaques and synapses (PubMed:12422219). .

Expression： Brain,Epithelium,Skeletal muscle,