Target:TIRAP
Fields:NF-kappa B signaling pathway;Toll-like receptor signaling pathway;Alcoholic liver disease;Pathogenic Escherichia coli infection;Salmonella infection;Pertussis;Tuberculosis;Hepatitis B;PD-L1 expression and PD-1 checkpoint pathway in cancer;Lipid and atherosclerosis
Gene Name:TIRAP
Protein Name:Toll/interleukin-1 receptor domain-containing adapter protein
Human Gene Id:114609
Human Swiss Prot No:P58753
Mouse Gene Id:117149
Mouse Swiss Prot No:Q99JY1
Immunogen:The antiserum was produced against synthesized peptide derived from human TIRAP. AA range:52-101
Specificity:TIRAP Polyclonal Antibody detects endogenous levels of TIRAP protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:TIRAP;MAL;Toll/interleukin-1 receptor domain-containing adapter protein;TIR domain-containing adapter protein;Adaptor protein Wyatt;MyD88 adapter-like protein
Molecular Weight(Da):24kD
Background: The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008],
Function:function:Adapter involved in the TLR4 signaling pathway in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, resulting in cytokine secretion and the inflammatory response.,polymorphism:Genetic variation in TIRAP can influence susceptibility or resistance to invasive pneumococcal disease, bacteremia, malaria and tuberculosi.,similarity:Contains 1 TIR domain.,subunit:Homodimer. Also forms heterodimers with MyD88. Binds to TLR4 and IRAK2 via their respective TIR domains. Binds to PKR and TBK1. Does not interact with IRAK1, nor TLR9.,tissue specificity:Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain.,
Subcellular Location:Cytoplasm . Cell membrane . Membrane . Colocalizes with DAB2IP at the plasma membrane.
Expression:Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain.