Target：FOXP3

Fields：Th17 cell differentiation;Inflammatory bowel disease

Gene Name：FOXP3

Protein Name：Forkhead box protein P3

Human Gene Id：50943

Human Swiss Prot No：Q9BZS1

Mouse Gene Id：20371

Mouse Swiss Prot No：Q99JB6

Immunogen：The antiserum was produced against synthesized peptide derived from the C-terminal region of human FOXP3. AA range:381-430

Specificity：FOXP3 Polyclonal Antibody detects endogenous levels of FOXP3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：FOXP3;IPEX;JM2;Forkhead box protein P3;Scurfin

Observed Band(KD)：47kD

Background： The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],

Function：disease:Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) [MIM:304790]; also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema. It is usually lethal in infancy.,function:Probable transcription factor. Plays a critical role in the control of immune response.,online information:FOXP3 entry,online information:FOXP3 mutation db,similarity:Contains 1 C2H2-type zinc finger.,similarity:Contains 1 fork-head DNA-binding domain.,

Subcellular Location：Nucleus . Cytoplasm . Predominantly expressed in the cytoplasm in activated conventional T-cells whereas predominantly expressed in the nucleus in regulatory T-cells (Treg). The 41 kDa form derived by proteolytic processing is found exclusively in the chromatin fraction of activated Treg cells (By similarity). .