Target：TPX2

Gene Name：TPX2

Protein Name：Targeting protein for Xklp2

Human Gene Id：22974

Human Swiss Prot No：Q9ULW0

Mouse Gene Id：72119

Mouse Swiss Prot No：A2APB8

Immunogen：The antiserum was produced against synthesized peptide derived from human DIL-2. AA range:301-350

Specificity：TPX2 Polyclonal Antibody detects endogenous levels of TPX2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TPX2;C20orf1;C20orf2;DIL2;HCA519;Targeting protein for Xklp2;Differentially expressed in cancerous and non-cancerous lung cells 2;DIL-2;Hepatocellular carcinoma-associated antigen 519;Protein fls353;Restricted expression prolifera

Observed Band(KD)：86kD

Background：developmental stage:Exclusively expressed in proliferating cells from the transition G1/S until the end of cytokinesis.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,subcellular location:During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus.,tissue specificity:Expressed in lung carcinoma cell lines but not in normal lung tissues.,

Function：developmental stage:Exclusively expressed in proliferating cells from the transition G1/S until the end of cytokinesis.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,subcellular location:During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus.,tissue specificity:Expressed in lung carcinoma cell lines but not in normal lung tissues.,

Subcellular Location：Nucleus . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, spindle pole . During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules. .

Expression：Expressed in lung carcinoma cell lines but not in normal lung tissues.