Target：TSH3

Gene Name：TSHZ3 KIAA1474 TSH3 ZNF537

Protein Name：Teashirt homolog 3 (Zinc finger protein 537)

Human Gene Id：57616

Human Swiss Prot No：Q63HK5

Mouse Swiss Prot No：Q8CGV9

Rat Swiss Prot No：D3ZKB9

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：TSH3 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：118kD

Background： This gene encodes a zinc-finger transcription factor that regulates smooth muscle cell differentiation in the developing urinary tract. Consistent with this role, mice in which this gene has been inactivated exhibit abnormal gene expression in urinary tract smooth muscle cell precursors and kidney defects including hydronephrosis. The encoded transcription factor comprises a gene silencing complex that inhibits caspase expression. Reduced expression of this gene and consequent caspase upregulation may be correlated with progression of Alzheimer's disease in human patients. [provided by RefSeq, Jul 2016],

Function：function:Transcriptional regulator involved in developmental processes .,similarity:Belongs to the teashirt C2H2-type zinc-finger protein family.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 5 C2H2-type zinc fingers.,

Subcellular Location：Nucleus . Cell projection, growth cone . Colocalizes with APBB1 in axonal growth cone (By similarity). Colocalizes with APBB1 in the nucleus. .

Expression：Expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease (PubMed:18776146, PubMed:19343227). Expressed in the fetal neocortex (PubMed:27668656).