Target：TSG-6

Gene Name：TNFAIP6

Protein Name：Tumor necrosis factor-inducible gene 6 protein

Human Gene Id：7130

Human Swiss Prot No：P98066

Mouse Gene Id：21930

Mouse Swiss Prot No：O08859

Immunogen：The antiserum was produced against synthesized peptide derived from human TSG6. AA range:21-70

Specificity：TSG-6 Polyclonal Antibody detects endogenous levels of TSG-6 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TNFAIP6;TSG6;Tumor necrosis factor-inducible gene 6 protein;Hyaluronate-binding protein;TNF-stimulated gene 6 protein;TSG-6;Tumor necrosis factor alpha-induced protein 6;TNF alpha-induced protein 6

Observed Band(KD)：31kD

Background： The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010],

Function：function:Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis.,induction:By TNF.,similarity:Contains 1 CUB domain.,similarity:Contains 1 Link domain.,subunit:Interacts with inter-alpha-inhibitor (I-alpha-I). Chondroitin sulfate may be required for the stability of the complex.,tissue specificity:Found in the synovial fluid of patients with rheumatoid arthritis.,

Subcellular Location：Secreted .

Expression：Expressed in airway epithelium and submucosal gland (at protein level). Colocalizes with bikunin at the ciliary border. Present in bronchoalveolar lavage fluid (at protein level) (PubMed:16873769). Expressed in mesenchymal stem cells (PubMed:16771708). Found in the synovial fluid of patients with rheumatoid arthritis.