Target:UBP10
Gene Name:USP10 KIAA0190
Protein Name:Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10)
Human Gene Id:9100
Human Swiss Prot No:Q14694
Mouse Swiss Prot No:P52479
Rat Swiss Prot No:Q3KR59
Immunogen:Synthesized peptide derived from part region of human protein
Specificity:UBP10 Polyclonal Antibody detects endogenous levels of protein.
Formulation:Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000 ELISA 1:5000-20000
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD):87kD
Background: Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013],
Function:catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,function:Ubiquitin specific protease are required to remove ubiquitin from specific proteins or peptides to which ubiquitin is attached.,similarity:Belongs to the peptidase C19 family.,subunit:Interacts with G3BP, which may regulate its function.,tissue specificity:Widely expressed.,
Subcellular Location:Cytoplasm . Nucleus . Early endosome . Cytoplasmic in normal conditions (PubMed:20096447). After DNA damage, translocates to the nucleus following phosphorylation by ATM (PubMed:20096447). .
Expression:Widely expressed.