Target：Wnt-1

Fields：mTOR signaling pathway;Wnt signaling pathway;Hippo signaling pathway;Signaling pathways regulating pluripotency of stem cells;Melanogenesis;Cushing syndrome;Alzheimer disease;Pathways of neurodegeneration - multiple diseases;Human papillomavirus infection;Pathways in cancer;Proteoglycans in cancer;Chemical carcinogenesis - receptor activation;Basal cell carcinoma;Breast cancer;Hepatocellular carcinoma;Gastric cancer

Gene Name：WNT1

Protein Name：Proto-oncogene Wnt-1

Human Gene Id：7471

Human Swiss Prot No：P04628

Mouse Gene Id：22408

Mouse Swiss Prot No：P04426

Immunogen：The antiserum was produced against synthesized peptide derived from human WNT1. AA range:301-350

Specificity：Wnt-1 Polyclonal Antibody detects endogenous levels of Wnt-1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：WNT1;INT1;Proto-oncogene Wnt-1;Proto-oncogene Int-1 homolog

Observed Band(KD)：45kD

Background： The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in

Function：function:Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters.,similarity:Belongs to the Wnt family.,subunit:Interacts with PORCN. Interacts with RSPO1, RSPO2 and RSPO3.,

Subcellular Location：Secreted, extracellular space, extracellular matrix . Secreted .

Expression： Testis,