Target:Wee 2
Fields:Cell cycle;Human immunodeficiency virus 1 infection
Gene Name:WEE2
Protein Name:Wee1-like protein kinase 2
Human Gene Id:494551
Human Swiss Prot No:P0C1S8
Mouse Swiss Prot No:Q66JT0
Immunogen:The antiserum was produced against synthesized peptide derived from human WEE2. AA range:151-200
Specificity:Wee 2 Polyclonal Antibody detects endogenous levels of Wee 2 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:WEE2;WEE1B;Wee1-like protein kinase 2;Wee1-like protein kinase 1B;Wee1B kinase
Observed Band(KD):60kD
Background:catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Phosphorylates and inhibits CDC2. May act as a negative regulator of entry into mitosis (G2 to M transition).,PTM:Phosphorylated .,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Expressed in testis.,
Function:catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Phosphorylates and inhibits CDC2. May act as a negative regulator of entry into mitosis (G2 to M transition).,PTM:Phosphorylated .,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Expressed in testis.,
Subcellular Location:Nucleus .
Expression:Expressed in oocytes (at protein level) (PubMed:29606300). May also be expressed in testis (PubMed:11029659).