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Wee 1 Polyclonal Antibody
Wee 1 Polyclonal Antibody
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Wee 1 Polyclonal Antibody
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经销商客户: ¥440.0
实验室客户: ¥600.0
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商品属性

Target:WEE1

Fields:Cell cycle;Human immunodeficiency virus 1 infection

Gene Name:WEE1

Protein Name:Wee1-like protein kinase

Human Gene Id:7465

Human Swiss Prot No:P30291

Mouse Gene Id:22390

Mouse Swiss Prot No:P47810

Rat Gene Id:308937

Rat Swiss Prot No:Q63802

Immunogen:The antiserum was produced against synthesized peptide derived from human WEE1. AA range:19-68

Specificity:Wee 1 Polyclonal Antibody detects endogenous levels of Wee 1 protein.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source:Polyclonal, Rabbit,IgG

Dilution:WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration:1 mg/ml

Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name:WEE1;Wee1-like protein kinase;WEE1hu;Wee1A kinase

Observed Band(KD):72kD

Background:WEE1 G2 checkpoint kinase(WEE1) Homo sapiens This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. [provided by RefSeq, Jul 2008],

Function:catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,cofactor:Binds 2 magnesium ions per subunit.,enzyme regulation:Synthesis is increased during S and G2 phases, presumably by an increase in transcription; activity is decreased by phosphorylation during m phase. Protein levels fall in M phase as a result of decreased synthesis combined with degradation. Activity seems to be negatively regulated by phosphorylation upon entry into mitosis, although N-terminal phosphorylation might also regulate the protein stability via protection from proteolysis or might regulate the subcellular location.,function:May act as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDC2 before the onset of mitosis. Its activity increases during S and G2 phases and decreases at M phase

Subcellular Location:Nucleus.

Expression: Amygdala,Blood,Epithelium,Human uterus endothel primary cell culture,Placenta,Skin,

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