Target：UBE4A

Fields：Ubiquitin mediated proteolysis

Gene Name：UBE4A

Protein Name：Ubiquitin conjugation factor E4 A

Human Gene Id：9354

Human Swiss Prot No：Q14139

Rat Gene Id：315608

Rat Swiss Prot No：Q6P7A2

Immunogen：Synthesized peptide derived from the N-terminal region of human UBE4A.

Specificity：UBE4A Polyclonal Antibody detects endogenous levels of UBE4A protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：UBE4A;KIAA0126;Ubiquitin conjugation factor E4 A

Observed Band(KD)：122kD

Background： This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011],

Function：function:Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunction with E1, E2, and E3.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the ubiquitin conjugation factor E4 family.,similarity:Contains 1 U-box domain.,

Subcellular Location：Cytoplasm .

Expression： Bone marrow,Platelet,Skeletal muscle,