Target：VRK3

Gene Name：VRK3

Protein Name：Inactive serine/threonine-protein kinase VRK3

Human Gene Id：51231

Human Swiss Prot No：Q8IV63

Mouse Swiss Prot No：Q8K3G5

Immunogen：Synthesized peptide derived from the Internal region of human VRK3.

Specificity：VRK3 Polyclonal Antibody detects endogenous levels of VRK3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：VRK3;Inactive serine/threonine-protein kinase VRK3;Serine/threonine-protein pseudokinase VRK3;Vaccinia-related kinase 3

Observed Band(KD)：53kD

Background：vaccinia related kinase 3(VRK3) Homo sapiens This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. In both human and mouse, this gene has substitutions at several residues within the ATP binding motifs that in other kinases have been shown to be required for catalysis. In vitro assays indicate the protein lacks phosphorylation activity. The protein, however, likely retains its substrate binding capability. This gene is widely expressed in human tissues and its protein localizes to the nucleus. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008],

Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Probable serine/threonine kinase.,similarity:Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.,similarity:Contains 1 protein kinase domain.,

Subcellular Location：Nucleus .

Expression： Brain,Liver,Skin,Testis,Trachea,