Target：UBE2A/B

Fields：Ubiquitin mediated proteolysis

Gene Name：UBE2A/UBE2B

Protein Name：Ubiquitin-conjugating enzyme E2 A/Ubiquitin-conjugating enzyme E2 B

Human Gene Id：7320

Human Swiss Prot No：P49459/P63146

Rat Gene Id：81816

Rat Swiss Prot No：P63149

Immunogen：Synthesized peptide derived from the C-terminal region of human UBE2A/B.

Specificity：UBE2A/B Polyclonal Antibody detects endogenous levels of UBE2A/B protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：UBE2A;RAD6A;Ubiquitin-conjugating enzyme E2 A;RAD6 homolog A;HR6A;hHR6A;Ubiquitin carrier protein A;Ubiquitin-protein ligase A;UBE2B;RAD6B;Ubiquitin-conjugating enzyme E2 B;RAD6 homolog B;HR6B;hHR6B;Ubiquitin carrier protein B;Ubiquitin-conjugating enzyme E2-17 kDa;Ubiquitin-protein ligase B

Observed Band(KD)：17kD

Background： The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013],

Function：catalytic activity:ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Catalyzes the covalent attachment of ubiquitin to other proteins. Required for postreplication repair of UV-damaged DNA.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the ubiquitin-conjugating enzyme family.,subunit:Interacts with RAD18.,

Subcellular Location：chromatin,nuclear chromatin,XY body,cytoplasm,cytosol,HULC complex,

Expression： Lung,Skin,Subthalamic nucleus,Thyroid,