Target：Relaxin Receptor 2

Fields：Neuroactive ligand-receptor interaction;Relaxin signaling pathway

Gene Name：RXFP2

Protein Name：Relaxin receptor 2

Human Gene Id：122042

Human Swiss Prot No：Q8WXD0

Mouse Gene Id：140498

Mouse Swiss Prot No：Q91ZZ5

Immunogen：The antiserum was produced against synthesized peptide derived from human RXFP2. AA range:113-162

Specificity：Relaxin Receptor 2 Polyclonal Antibody detects endogenous levels of Relaxin Receptor 2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：RXFP2;GPR106;GREAT;LGR8;Relaxin receptor 2;G-protein coupled receptor 106;G-protein coupled receptor affecting testicular descent;Leucine-rich repeat-containing G-protein coupled receptor 8;Relaxin family peptide receptor 2

Observed Band(KD)：86kD

Background： This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009],

Function：caution:It is uncertain whether Met-1 or Met-18 is the initiator.,disease:Defects in RXFP2 are a cause of cryptorchidism [MIM:219050]; also known as impaired testicular descent. It is one of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer.,function:Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3).,similarity:Belongs to the G-protein coupled receptor 1 family.,similarity:Contains 1 LDL-receptor class A domain.,similarity:Contains 10 LRR (leucine-rich) repeats.,tissue specificity:Expressed mainly in the brain, kidney, muscle, testis, thyroid, uterus, peripheral blood cells and bone marrow.,

Subcellular Location：Cell membrane; Multi-pass membrane protein.

Expression：Expressed mainly in the brain, kidney, muscle, testis, thyroid, uterus, peripheral blood cells and bone marrow.