Target:5NTC
Fields:Purine metabolism;Pyrimidine metabolism;Nicotinate and nicotinamide metabolism;Metabolic pathways;Nucleotide metabolism
Gene Name:NT5C2 NT5B NT5CP PNT5
Protein Name:Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (Cytosolic 5'-nucleotidase II)
Human Gene Id:22978
Human Swiss Prot No:P49902
Mouse Swiss Prot No:Q3V1L4
Immunogen:Synthesized peptide derived from part region of human protein
Specificity:5NTC Polyclonal Antibody detects endogenous levels of protein.
Formulation:Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500-2000 ELISA 1:5000-20000
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD):61kD
Background: This gene encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides. [provided by RefSeq, Oct 2011],
Function:catalytic activity:A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.,cofactor:Binds 1 magnesium ion per subunit.,disease:Aberration of this enzyme may be related to the urate production in hyperuricemia and gout.,enzyme regulation:Allosterically activated by various compounds, including ATP.,function:May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides.,similarity:Belongs to the 5'(3')-deoxyribonucleotidase family.,subunit:Homotetramer.,
Subcellular Location:Cytoplasm, cytosol .
Expression:Widely expressed.