Target：IL-1α

Fields：MAPK signaling pathway;Cytokine-cytokine receptor interaction;Necroptosis;Cellular senescence;Osteoclast differentiation;Hematopoietic cell lineage;Non-alcoholic fatty liver disease;AGE-RAGE signaling pathway in diabetic complications;Type I diabetes mellitus;Alzheimer disease;Prion disease;Pathways of neurodegeneration - multiple diseases;Pertussis;Leishmaniasis;Tuberculosis;Measles;Influenza A;Inflammatory bowel disease;Rheumatoid arthritis;Graft-versus-host disease;Fluid shear stress and atherosclerosis

Gene Name：IL1A

Protein Name：Interleukin-1 alpha

Human Gene Id：3552

Human Swiss Prot No：P01583

Mouse Gene Id：16175

Mouse Swiss Prot No：P01582

Rat Gene Id：24493

Rat Swiss Prot No：P16598

Immunogen：The antiserum was produced against synthesized peptide derived from human IL-1alpha. AA range:8-57

Specificity：IL-1α Polyclonal Antibody detects endogenous levels of IL-1α protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：IL1A;IL1F1;Interleukin-1 alpha;IL-1 alpha;Hematopoietin-1

Molecular Weight(Da)：31kD

Background： The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008],

Function：domain:The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.,function:Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.,online information:Interleukin-1 entry,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the IL-1 family.,subcellular location:The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.,subunit:Mono

Subcellular Location：Cytoplasm . Secreted . The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). .

Expression： Lung,